Dosing Guidlines for Children
Drug Detail for Pediatric Drugs
Methadone
Analgesics
Narcotics and Narcotic Antagonists
- Metabolism/Excretion
- Hepatic, minimal renal excretion
- Plasma Protein Binding %
- 60-90
- Dose for Normal Renal Function
- Oral = 0.05-0.2 mg/kg dose q4-6h for 3-4 doses, then q8-12h; IV = 0.03-0.1 mg/kg dose q4-6h for 3-4 doses, then q8-12h
- Adjustment for Renal Function GFR, mL/min/1.73m2 30-50
- q6-8h
- Adjustment for Renal Function GFR, mL/min/1.73m2 10-29
- q8-12h
- AdAdjustment for Renal Function GFR, mL/min/1.73m2 <10
- q12-24h
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: q12-24h
- Supplement for Dialysis [Recommendation Level]: PD
- PD: q12-24h
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: q8-12h, titrate to effect, after 4-5 doses spread out interval to q8-24h, [D]
- References
- Furlan V, Hafi A, Dessalles MC, Bouchez J, Charpentier B, Taburet AM. Methadone is poorly removed by haemodialysis [Letter]. Nephrol Dial Transplant. 1999; 14: 254-5. [PMID: 10052536]
- Toxicity Notes
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