Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Amiloride
Antihypertensive and Cardiovascular Agents
Cardiovascular Agents
Diuretics
- General Toxicity Notes
- Natriuretic drugs may cause extracellular fluid volume depletion.
- Excreted Unchanged %
- 50
- Half-Life (NormalESRD) hours
- 6-21/10-144
- Plasma Protein Binding %
- 30-40
- Volume of Distribution L/kg
- 5.0-5.2
- Dose for Normal Renal Function
- 5.0 mg q24h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 50% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- Avoid [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Avoid, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Avoid, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Not applicable, [D]
- References
- George CF. Amiloride handling in renal failure. Br J Clin Pharmacol. 1980; 9: 94-5. [PMID: 7356897] / Spahn H, Reuter K, Mutschler E, Gerok W, Knauf H. Pharmacokinetics of amiloride in renal and hepatic disease. Eur J Clin Pharmacol. 1987; 33: 493-8. [PMID: 3428342]
- Toxicity Notes
- Hyperkalemia with GFR <30 mL/min, especially in diabetics. Hyperchloremic metabolic acidosis.