Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Pentazocine
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2-5/No data
- Plasma Protein Binding %
- 50-75
- Volume of Distribution L/kg
- 5
- Dose for Normal Renal Function
- 50 mg q4h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None
- Supplement for Dialysis [Recommendation Level]: PD
- PD: No data
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Not applicable, [D]
- References
- Forycki Z, Martens F, Thalhofer S, Ibe K. Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis. Blood Purif. 1985; 3: 109-19. [PMID: 2869770] / Mather LE. Opioid pharmacokinetics in relation to their effects. Anaesth Intensive Care. 1987; 15: 15-22. [PMID: 2882700] / Yeh SY, Todd GD, Johnson RE, Gorodetzky CW, Lange WR. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986; 39: 669-76. [PMID: 3709032]
- Toxicity Notes
-