Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Methadone
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 13-58/No data
- Plasma Protein Binding %
- 60-90
- Volume of Distribution L/kg
- 3-6
- Dose for Normal Renal Function
- 2.5-10 mg q6-8h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50-75% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, titrate, [D]
- References
- Bertschy G. Methadone maintenance treatment: an update. Eur Arch Psychiatry Clin Neurosci. 1995; 245: 114-24. [PMID: 7654787] / Inturrisi CE, Colburn WA, Kaiko RF, Houde RW, Foley KM. Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther. 1987; 41: 392-401. [PMID: 3829576] / Quinn DI, Wodak A, Day RO. Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users. Clin Pharmacokinet. 1997; 33: 344-400. [PMID: 9391747] / Sö we J. High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment. Clin Pharmacokinet. 1986; 11: 87-106. [PMID: 3514045]
- Toxicity Notes
-