Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Meperidine
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2-7/7-32
- Plasma Protein Binding %
- 70
- Volume of Distribution L/kg
- 4-5
- Dose for Normal Renal Function
- 50-100 mg q3-4h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Avoid
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Avoid
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Avoid, [D]
- References
- Clark RF, Wei EM, Anderson PO. Meperidine: therapeutic use and toxicity. J Emerg Med. 1995; 13: 797-802. [PMID: 8747629] / Davies G, Kingswood C, Street M. Pharmacokinetics of opioids in renal dysfunction. Clin Pharmacokinet. 1996; 31: 410-22. [PMID: 8968655] / Sjö strö m S, Hartvig P, Persson MP, Tamsen A. Pharmacokinetics of epidural morphine and meperidine in humans. Anesthesiology. 1987; 67: 877-88. [PMID: 2891328] / Sjö strö m S, Tamsen A, Persson MP, Hartvig P. Pharmacokinetics of intrathecal morphine and meperidine in humans. Anesthesiology. 1987; 67: 889-95. [PMID: 2891329]
- Toxicity Notes
- Normeperidine, an active metabolite, accumulates in ESRD and may cause seizures. Protein binding is reduced in ESRD. 20-25% excreted unchanged in acidic urine.