Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Bisoprolol
Antihypertensive and Cardiovascular Agents
Antihypertensive Drugs
Beta-Blockers
- General Toxicity Notes
- Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
- Excreted Unchanged %
- 50
- Half-Life (NormalESRD) hours
- 9-13/18-24
- Plasma Protein Binding %
- 30-35
- Volume of Distribution L/kg
- 3
- Dose for Normal Renal Function
- 5 mg q24h
- Second Dose
- Second Dose: 5-20 mg q24h
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose after dialysis, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50,titrate, [D]
- References
- Johns TE, Lopez LM. Bisoprolol: is this just another beta-blocker for hypertension or angina? Ann Pharmacother. 1995; 29: 403-14. [PMID: 7633020] / Kanegae K, Hiroshige K, Suda T, Iwamoto M, Ohta T, Nakashima Y, et al. Pharmacokinetics of bisoprolol and its effect on dialysis refractory hypertension. Int J Artif Organs. 1999; 22: 798-804. [PMID: 10654875] / Lancaster SG, Sorkin EM. Bisoprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris. Drugs. 1988; 36: 256-85. [PMID: 2903820]
- Toxicity Notes
-