Dosing Guidlines for Adults

Drug Detail for Adult Drugs

Atenolol

Antihypertensive and Cardiovascular Agents

Antihypertensive Drugs

Beta-Blockers

General Toxicity Notes: Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Excreted Unchanged %: 85
Half-Life (NormalESRD) hours: 6-7/15-35
Plasma Protein Binding %: 3
Volume of Distribution L/kg: 1.1
Dose for Normal Renal Function: 50-100 mg q24h
Second Dose
Adjustment for Renal Failure Method: D
Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]: 50-100 mgq24h [A]
Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]: 25-50 mgq24h [A]
Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]: 25 mg q24h [A]
Supplement for Dialysis [Recommendation Level]: IHD: IHD: 25-50 mg after dialysis, [A]
Supplement for Dialysis [Recommendation Level]: PD: PD: Dose for GFR <10, [A]
Supplement for Dialysis [Recommendation Level]: CRRT: CRRT: Dose for GFR 10-50,titrate, [D]
References: Campese VM, Feinstein EI, Gura V, Mason WD, Massry SG. Pharmacokinetics of atenolol in patients treated with chronic hemodialysis or peritoneal dialysis. J Clin Pharmacol. 1985; 25: 393-5. [PMID: 4031118] / Flouvat B, Decourt S, Aubert P, Potaux L, Domart M, Goupil A, et al. Pharmaco-kinetics of atenolol in patients with terminal renal failure and influence of haemodialysis. Br J Clin Pharmacol. 1980; 9: 379-85. [PMID: 7378254] / Salahudeen AK, Wilkinson R, McAinsh J, Bateman DN. Atenolol pharmacokinetics in patients on continuous ambulatory peritoneal dialysis. Br J Clin Pharmacol. 1984; 18: 457-60. [PMID: 6487486] / Sassard J, Pozet N, McAinsh J, Legheand J, Zech P. Pharmacokinetics of atenolol in patients with renal impairment. Eur J Clin Pharmacol. 1977; 12: 175-80. [PMID: 590303] / Wadworth AN, Murdoch D, Brogden RN. Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs. 1991; 42: 468-510. [PMID: 1720383]
Toxicity Notes: Accumulates in ESRD.