Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Acebutolol
Antihypertensive and Cardiovascular Agents
Antihypertensive Drugs
Beta-Blockers
- General Toxicity Notes
- Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
- Excreted Unchanged %
- 30-40
- Half-Life (NormalESRD) hours
- 3-13/7
- Plasma Protein Binding %
- 26
- Volume of Distribution L/kg
- 1.2
- Dose for Normal Renal Function
- 400-600 mg q24h or bid
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 50% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 25% [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose after dialysis, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50,titrate, [D]
- References
- Fleurot O, Lecocq B, Lecocq V, Le Liboux A, Montay G, Frydman A, et al. A comparative pharmacokinetic and pharmacodynamic study of conventional and sustained-release preparations of acebutolol in healthy volunteers. Fundam Clin Pharmacol. 1991; 5: 601-9. [PMID: 1778538] / Piquette-Miller M, Foster RT, Kappagoda CT, Jamali F. Pharmacokinetics of acebutolol enantiomers in humans. J Pharm Sci. 1991; 80: 313-6. [PMID: 1865329] / Singh BN, Thoden WR, Ward A. Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia. Drugs. 1985; 29: 531-69. [PMID: 3891306] / Tjandramaga TB. Altered pharmacokinetics of beta-adrenoceptor blocking drugs in patients with renal insufficiency. Arch Int Pharmacodyn Ther. 1980; Suppl: 38-53. [PMID: 6106457]
- Toxicity Notes
- Active metabolites with long half-life.