Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Thiopental
Sedatives, Hypnotics, and Other Drugs Used in Psychiatry
Barbiturates
- General Toxicity Notes
- May cause excessive sedation and increase osteomalacia in ESRD. Charcoal hemoperfusion and hemodialysis more effective than peritoneal dialysis. For poisoning.
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 3.8/6-18
- Plasma Protein Binding %
- 72-86
- Volume of Distribution L/kg
- 1.0-1.5
- Dose for Normal Renal Function
- Anesthesia induction (individualized)
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 75% [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Browne TR. The pharmacokinetics of agents used to treat status epilepticus. Neurology. 1990; 40: 28-32. [PMID: 2185438]
- Toxicity Notes
-