Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Fentanyl
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2-7/No data
- Plasma Protein Binding %
- 80-84
- Volume of Distribution L/kg
- 2-4
- Dose for Normal Renal Function
- Anesthetic induction (individualized)
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Not applicable
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Not applicable
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, titrate, [B]
- References
- Cleary JF. Pharmacokinetic and pharmacodynamic issues in the treatment of breakthrough pain. Semin Oncol. 1997; 24: S16-13-9. [PMID: 9381223] / Davies G, Kingswood C, Street M. Pharmacokinetics of opioids in renal dysfunction. Clin Pharmacokinet. 1996; 31: 410-22. [PMID: 8968655] / Reilly CS, Wood AJ, Wood M. Variability of fentanyl pharmacokinetics in man. Computer predicted plasma concentrations for three intravenous dosage regimens. Anaesthesia. 1985; 40: 837-43. [PMID: 4051149] / Wagner BK, O’ Hara DA. Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients. Clin Pharmacokinet. 1997; 33: 426-53. [PMID: 9435992]
- Toxicity Notes
-