Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Albuterol (inhaled)
Miscellaneous Agents
Bronchodilators
- General Toxicity Notes
-
- Excreted Unchanged %
- 28
- Half-Life (NormalESRD) hours
- 2-4/4
- Plasma Protein Binding %
- 7
- Volume of Distribution L/kg
- 7.2-9
- Dose for Normal Renal Function
- 2 inhalations q4-6h
- Second Dose
-
- Adjustment for Renal Failure Method
-
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: 100%, [D]
- References
- Anderson PJ, Zhou X, Breen P, Gann L, Logsdon TW, Compadre CM, et al. Pharmacokinetics of (R,S)-Albuterol after aerosol inhalation in healthy adult volunteers. J Pharm Sci. 1998; 87: 841-4. [PMID: 9649352] / Boulton DW, Fawcett JP. Pharmacokinetics and pharmacodynamics of single oral doses of albuterol and its enantiomers in humans. Clin Pharmacol Ther. 1997; 62: 138-44. [PMID: 9284849] / Mohamed MH, Lima JJ, Eberle LV, Self TH, Johnson JA. Effects of gender and race on albuterol pharmacokinetics. Pharmacotherapy. 1999; 19: 157-61. [PMID: 10030766] / Morgan DJ, Paull JD, Richmond BH, Wilson-Evered E, Ziccone SP. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. Br J Clin Pharmacol. 1986; 22: 587-93. [PMID: 3790406] / Powell ML, Chung M, Weisberger M, Gural R, Radwanski E, Symchowicz S, et al. Multiple-dose albuterol kinetics. J Clin Pharmacol. 1986; 26: 643-6. [PMID: 3793958] / Rey E, Luquel L, Richard MO, Mory B, Offenstadt G, Olive G. Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects. Eur J Clin Pharmacol. 1989; 37: 387-9. [PMID: 2598971]
- Toxicity Notes
- Because of its gradual absorption from the bronchi, systemic levels of albuterol are low after inhalation at recommended doses. Nebulized albuterol therapy decreases plasma potassium concentrations in patients on hemodialysis.