Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Piroxicam
Miscellaneous Agents
Arthritis and Gout Agents: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
- General Toxicity Notes
- May decrease renal function. Decrease platelet aggregation. Nephrotic syndrome, interstitial nephritis, hyperkalemia, sodium retention.
- Excreted Unchanged %
- 10
- Half-Life (NormalESRD) hours
- 45-55/Unchanged
- Plasma Protein Binding %
- >99
- Volume of Distribution L/kg
- 0.12-0.15
- Dose for Normal Renal Function
- 20 mg q24h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100% [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None, [A]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [B]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Not applicable
- References
- Brogden RN, Heel RC, Speight TM, Avery GS. Piroxicam. A reappraisal of its pharmacology and therapeutic efficacy. Drugs. 1984; 28: 292-323. [PMID: 6386426] / Olkkola KT, Brunetto AV, Mattila MJ. Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents. Clin Pharmacokinet. 1994; 26: 107-20. [PMID: 8162655]
- Toxicity Notes
-