Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Hydroxyurea
Miscellaneous Agents
Antineoplastic Agents
- General Toxicity Notes
- Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
- Excreted Unchanged %
- >50
- Half-Life (NormalESRD) hours
- No data
- Plasma Protein Binding %
- No data
- Volume of Distribution L/kg
- 0.5
- Dose for Normal Renal Function
- 20-30 mg/kg q24h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 50% [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 20% [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose after dialysis, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Drugs of choice for cancer chemotherapy. Med Lett Drugs Ther. 1997; 39: 21-8. [PMID: 9081147] / Muggia FM, Von Hoff DD. In: Speight TM, Holford N, eds. Avery’ s Drug Treatment, 4th ed. Auckland: ADIS International; 1997: 1255.
- Toxicity Notes
-