Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Benazepril
Antihypertensive and Cardiovascular Agents
Antihypertensive Drugs
Angiotensin-Converting Enzyme (ACE) Inhibitors
- General Toxicity Notes
- Blood pressure is the best guide to dose and interval. Hypotensive effects magnified by natriuretic agents or sodium depletion. May cause hyperkalemia, metabolic acidosis. Acute renal dysfunction with bilateral or transplant renal artery stenosis, low renal perfusion pressure. Dry cough in 5-10% of patients.
- Excreted Unchanged %
- 54
- Half-Life (NormalESRD) hours
- 10-11/30
- Plasma Protein Binding %
- 96
- Volume of Distribution L/kg
- 0.15
- Dose for Normal Renal Function
- 10 mg q24h
- Second Dose
- Second Dose: 10-40 mg q12-24h
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 50-75% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 25-50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50,titrate, [D]
- References
- Balfour JA, Goa KL. Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. Drugs. 1991; 42: 511-39. [PMID: 1720384] / Shionoiri H, Ueda S, Minamisawa K, Minamisawa M, Takasaki I, Sugimoto K, et al. Pharmacokinetics and pharmacodynamics of benazepril in hypertensive patients with normal and impaired renal function. J Cardiovasc Pharmacol. 1992; 20: 348-57. [PMID: 1279278]
- Toxicity Notes
-