Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Codeine
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2.5-3.5/No data
- Plasma Protein Binding %
- 7
- Volume of Distribution L/kg
- 3-4
- Dose for Normal Renal Function
- 30-60 mg q4-6h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: No data
- Supplement for Dialysis [Recommendation Level]: PD
- PD: No data
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, titrate, [D]
- References
- Davies G, Kingswood C, Street M. Pharmacokinetics of opioids in renal dysfunction. Clin Pharmacokinet. 1996; 31: 410-22. [PMID: 8968655] / Elseviers MM, De Broe ME. Combination analgesic involvement in the pathogenesis of analgesic nephropathy: the European perspective. Am J Kidney Dis. 1996; 28: S48-55. [PMID: 8669430] / Quiding H, Anderson P, Bondesson U, Boré us LO, Hynning PA. Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration. Eur J Clin Pharmacol. 1986; 30: 673-7. [PMID: 3770062]
- Toxicity Notes
-