Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Streptokinase
Miscellaneous Agents
Anticoagulants
- General Toxicity Notes
-
- Excreted Unchanged %
- None
- Half-Life (NormalESRD) hours
- 0.6-1.5/No data
- Plasma Protein Binding %
- No data
- Volume of Distribution L/kg
- 0.02-0.08
- Dose for Normal Renal Function
- 250,000 U load, then 100,000 U/h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100% [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Grierson DS, Bjornsson TD. Pharmacokinetics of streptokinase in patients based on amidolytic activator complex activity. Clin Pharmacol Ther. 1987; 41: 304-13. [PMID: 3816018]
- Toxicity Notes
- Rarely used because of newer agents.