Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Heparin (low-molecular-weight)
Miscellaneous Agents
Anticoagulants
- General Toxicity Notes
-
- Excreted Unchanged %
- No data
- Half-Life (NormalESRD) hours
- 2.2-6.0/4-10
- Plasma Protein Binding %
- No data
- Volume of Distribution L/kg
- 0.06-0.13
- Dose for Normal Renal Function
- 30-40 mg bid
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Dose for GFR <10, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: 50% and monitor Xa, [D]
- References
- Weitz JI. Low-molecular-weight heparins. N Engl J Med. 1997; 337: 688-98. [PMID: 9278467]
- Toxicity Notes
- Bleeding may be enhanced in patients with uremic platelet defects.