Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Oseltamivir
Antimicrobial Agents
Antiviral Agents
- General Toxicity Notes
-
- Excreted Unchanged %
- 99
- Half-Life (NormalESRD) hours
- 6-10/>20
- Plasma Protein Binding %
- 3
- Volume of Distribution L/kg
- 0.3-0.4
- Dose for Normal Renal Function
- 75 mg bid for treatment; qd for prophylaxis
- Second Dose
-
- Adjustment for Renal Failure Method
-
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100 [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- qd (treatment); qod (prophylaxis) [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- See notes [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: See notes, [B]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: See notes, [B]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: 100%, [D]
- References
- He G, Massarella J, Ward P. Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802. Clin Pharmacokinet. 1999; 37: 471-84. [PMID: 10628898]
- Toxicity Notes
- Can use full doses for CrCl >30 mL/min. For CrCl <30 mL/min, pharmacokinetic parameters for 75 mg qod predict adequate concentrations for treatment but efficacy not tested. For PD, 30 mg weekly or twice weekly predicts adequate concentrations but efficacy not tested. For HD, 30 mg on nondialysis days predicts adequate concentrations for treatment but efficacy not tested. Drug has a wide safety margin so appears to be little risk of higher-than-usual concentrations in renal failure.