Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Rifabutin
Antimicrobial Agents
Antimycobacterial Antibiotics
- General Toxicity Notes
-
- Excreted Unchanged %
- 5-10
- Half-Life (NormalESRD) hours
- 16-69/Unchanged
- Plasma Protein Binding %
- 71-89
- Volume of Distribution L/kg
- 8.2-9.3
- Dose for Normal Renal Function
- 300 mg q24h
- Second Dose
-
- Adjustment for Renal Failure Method
-
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100%[A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100%[A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100%[A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: 100%, [B]
- References
- Bassilios N, Launay-Vacher V, Hamani AA, Masias L, Peytavin G, Fau JB, et al. Pharmacokinetics and dosage adjustment of rifabutin in a haemodialysis patient [Letter]. Nephrol Dial Transplant. 2002; 17: 531-2. [PMID: 11865118] / Narang PK, Schoenfelder J, Bianchine JR. Impact of altered rifabutin disposition in renal disease on its safety in AIDS patients. AIDS. 1992; 6(Suppl 1): 90. [PMID unavailable] / Skinner MH, Hsieh M, Torseth J, Pauloin D, Bhatia G, Harkonen S, et al. Pharmacokinetics of rifabutin. Antimicrob Agents Chemother. 1989; 33: 1237-41. [PMID: 2552902]
- Toxicity Notes
-