Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Pyrazinamide
Antimicrobial Agents
Antimycobacterial Antibiotics
- General Toxicity Notes
-
- Excreted Unchanged %
- 1-3
- Half-Life (NormalESRD) hours
- 9/26
- Plasma Protein Binding %
- 5
- Volume of Distribution L/kg
- 0.75-1.3
- Dose for Normal Renal Function
- 15-30 mg/kg (up to 2.5 g) q24h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100%[A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100%[A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50-100%[A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: 40 mg/kg 24 hr before each 3/wk dialysis, [B]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: 100%, [B]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Lacroix C, Hermelin A, Guiberteau R, Guyonnaud C, Nouveau J, Duwoos H, et al. Haemodialysis of pyrazinamide in uraemic patients. Eur J Clin Pharmacol. 1989; 37: 309-11. [PMID: 2612545] / Stamatakis G, Montes C, Trouvin JH, Farinotti R, Fessi H, Kenouch S, et al. Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. Clin Nephrol. 1988; 30: 230-4. [PMID: 3214968] / Woo J, Leung A, Chan K, Lai KN, Teoh R. Pyrazinamide and rifampicin regimens for patients on maintenance dialysis. Int J Artif Organs. 1988; 11: 181-5. [PMID: 3403055]
- Toxicity Notes
- Impairs urate excretion. Can precipitate gout. Alternative dose of 25-30 mg/kg after each thrice weekly hemodialysis treatment has been suggested.