Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Butorphanol
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2-4/No data
- Plasma Protein Binding %
- 80
- Volume of Distribution L/kg
- 9-11
- Dose for Normal Renal Function
- 2 mg q3-4h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 75% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 50% [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: No data
- Supplement for Dialysis [Recommendation Level]: PD
- PD: No data
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, titrate, [D]
- References
- Gillis JC, Benfield P, Goa KL. Transnasal butorphanol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute pain management. Drugs. 1995; 50: 157-75. [PMID: 7588085] / Ramsey R, Higbee M, Maesner J, et al. Influence of age on the pharmacokinetics of butorphanol. Pharmacol Toxicol. 1987; 60(Suppl 2): 8-16. [PMID unavailable]
- Toxicity Notes
-