Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Norfloxacin
Antimicrobial Agents
Antibacterial Antibiotics
Quinolone Antibiotics
- General Toxicity Notes
- Most agents in this group are malabsorbed in the presence of compounds that contain metals such as magnesium, calcium, aluminum, and iron. Poorly absorbed with antacids, sucralfate, and phosphate binders.
- Excreted Unchanged %
- 30
- Half-Life (NormalESRD) hours
- 3.5-6.5/8
- Plasma Protein Binding %
- 14
- Volume of Distribution L/kg
- <0.5
- Dose for Normal Renal Function
- 400 mg q12h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- q12h [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- q12-24h [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 400 mg q24h [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose for GFR <10
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Dose for GFR <10
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Not applicable
- References
- Eliopoulos GM. New quinolones: pharmacology, pharmacokinetics, and dosing in patients with renal insufficiency. Rev Infect Dis. 1988; 10 Suppl 1: S102-5. [PMID: 3279486] / Fillastre JP, Leroy A, Moulin B, Dhib M, Borsa-Lebas F, Humbert G. Pharmaco-kinetics of quinolones in renal insufficiency. J Antimicrob Chemother. 1990; 26 Suppl B: 51-60. [PMID: 2124213] / Holmes B, Brogden RN, Richards DM. Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985; 30: 482-513. [PMID: 3908074] / Wolfson JS, Hooper DC. Pharmacokinetics of quinolones: newer aspects. Eur J Clin Microbiol Infect Dis. 1991; 10: 267-74. [PMID: 1864287]
- Toxicity Notes
-