Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Ticarcillin/ Clavulonate
Antimicrobial Agents
Antibacterial Antibiotics
Penicillins
- General Toxicity Notes
-
- Excreted Unchanged %
- 85
- Half-Life (NormalESRD) hours
- 1.2/11-16
- Plasma Protein Binding %
- 45-60
- Volume of Distribution L/kg
- 0.14-0.21
- Dose for Normal Renal Function
- 3.1 g q4h
- Second Dose
-
- Adjustment for Renal Failure Method
- D, I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100%[A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 3.1 g q8-12h[A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 2 g q12h[A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose for GFR <10 and 3.1 g after dialysis
- Supplement for Dialysis [Recommendation Level]: PD
- PD: 3.1 g q12h
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Parry MF, Neu HC. Pharmacokinetics of ticarcillin in patients with abnormal renal function. J Infect Dis. 1976; 133: 46-9. [PMID: 1107435]
- Toxicity Notes
- Sodium 5.2 mEq/g.