Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Lincomycin
Antimicrobial Agents
Antibacterial Antibiotics
Miscellaneous Antibacterial Antibiotics
- General Toxicity Notes
-
- Excreted Unchanged %
- 10-15
- Half-Life (NormalESRD) hours
- 4-5/10-20
- Plasma Protein Binding %
- 70-80
- Volume of Distribution L/kg
- 0.31-0.6
- Dose for Normal Renal Function
- 0.5 g q6h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- q6h[D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- q6-12h [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- q12-24h [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Golper TA, Gleason JR, Vincent HH, et al. Drug removal during high efficiency and high flux hemodialysis. Contemp Iss Nephrol. 1993; 27: 175-208. [PMID unavailable] / Keane WF, Everett ED, Golper TA, Gokal R, Halstenson C, Kawaguchi Y, et al. Peritoneal dialysis-related peritonitis treatment recommendations. 1993 update. The Ad Hoc Advisory Committee on Peritonitis Management. International Society for Peritoneal Dialysis. Perit Dial Int. 1993; 13: 14-28. [PMID: 8443273] / Malacoff RF, Finkelstein FO, Andriole VT. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin. Antimicrob Agents Chemother. 1975; 8: 574-80. [PMID: 1211913] / St Peter WL, Redic-Kill KA, Halstenson CE. Clinical pharmacokinetics of antibiotics in patients with impaired renal function. Clin Pharmacokinet. 1992; 22: 169-210. [PMID: 1559311]
- Toxicity Notes
-