Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Acetylsalicylic acid (aspirin)
Analgesics
Non-Narcotics
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic (renal)
- Half-Life (NormalESRD) hours
- 2-3/Unchanged
- Plasma Protein Binding %
- 80-90
- Volume of Distribution L/kg
- 0.1-0.2
- Dose for Normal Renal Function
- 650 mg q4h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- q4h [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- q4-6h [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- Avoid [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Dose after dialysis
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Clissold SP. Aspirin and related derivatives of salicylic acid. Drugs. 1986; 32 Suppl 4: 8-26. [PMID: 3552588] / Montgomery PR, Berger LG, Mitenko PA, Sitar DS. Salicylate metabolism: effects of age and sex in adults. Clin Pharmacol Ther. 1986; 39: 571-6. [PMID: 3698465] / Montgomery PR, Sitar DS. Acetylsalicylic acid metabolites in blood and urine after plain and enteric-coated tablets. Biopharm Drug Dispos. 1986; 7: 21-5. [PMID: 3955197] / Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet. 1985; 10: 164-77. [PMID: 3888490]
- Toxicity Notes
- Nephrotoxic in high doses. May decrease GFR when renal blood flow is prostaglandin dependent. Excretion enhanced in alkaline urine. May add to uremic gastrointestinal and hematologic symptoms. Protein binding reduced in ESRD. 5% excreted unchanged in acidic urine, 85% in alkaline urine.