Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Cefotetan
Antimicrobial Agents
Antibacterial Antibiotics
Cephalosporin Antibiotics
- General Toxicity Notes
-
- Excreted Unchanged %
- 75
- Half-Life (NormalESRD) hours
- 3.5/13-25
- Plasma Protein Binding %
- 85
- Volume of Distribution L/kg
- 0.15
- Dose for Normal Renal Function
- 1-2 g q12h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 1-2 g q24h [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 1-2 g q48h [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: 1 g after dialysis
- Supplement for Dialysis [Recommendation Level]: PD
- PD: 1 g/d
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: 1-2 g q24h, [D]
- References
- Browning MJ, Holt HA, White LO, Chapman ST, Banks RA, Reeves DS, et al. Pharmacokinetics of cefotetan in patients with end-stage renal failure on maintenance dialysis. J Antimicrob Chemother. 1986; 18: 103-6. [PMID: 3463556] / Ohkawa M, Hirano S, Tokunaga S, Motoi I, Shoda R, Ikeda A, et al. Pharmacokinetics of cefotetan in normal subjects and patients with impaired renal function. Antimicrob Agents Chemother. 1983; 23: 31-5. [PMID: 6572490] / Ward A, Richards DM. Cefotetan. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985; 30: 382-426. [PMID: 3905336]
- Toxicity Notes
-