Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Cefamandole
Antimicrobial Agents
Antibacterial Antibiotics
Cephalosporin Antibiotics
- General Toxicity Notes
-
- Excreted Unchanged %
- 50-100
- Half-Life (NormalESRD) hours
- 1/6-11
- Plasma Protein Binding %
- 75
- Volume of Distribution L/kg
- 0.16-0.25
- Dose for Normal Renal Function
- 0.5-1 g q4-8h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- q6h[A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- q6-8h [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- q8-12h [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: 0.5-1 g after dialysis
- Supplement for Dialysis [Recommendation Level]: PD
- PD: 0.5-1 g q12h
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Czerwinski AW, Pederson JA. Pharmacokinetics of cefamandole in patients with renal impairment. Antimicrob Agents Chemother. 1979; 15: 161-4. [PMID: 426510] / Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefa-mandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979; 26: 592-9. [PMID: 498702] / Pancorbo S, Comty C. Pharmacokinetics of cefamandole in patients undergoing continuous ambulatory peritoneal dialysis. Perit Dial Bull. 1983; 2: 135-7. [PMID unavailable]
- Toxicity Notes
-