Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Acetaminophen
Analgesics
Non-Narcotics
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2/2
- Plasma Protein Binding %
- 20-30
- Volume of Distribution L/kg
- 1-2
- Dose for Normal Renal Function
- 650 mg q4h
- Second Dose
-
- Adjustment for Renal Failure Method
- I
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- q4h [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- q6h [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- q8h [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50,[B]
- References
- Agarwal R, Farber MO. Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile? Clin Nephrol. 2002; 57: 167-70. [PMID: 11863129] / Blantz RC. Acetaminophen: acute and chronic effects on renal function. Am J Kidney Dis. 1996; 28: S3-6. [PMID: 8669426] / Clissold SP. Paracetamol and phenacetin. Drugs. 1986; 32 Suppl 4: 46-59. [PMID: 3552585] / D’ Arcy PF. Paracetamol. Adverse Drug React Toxicol Rev. 1997; 16: 9-14. [PMID: 9192054] / Segasothy M, Suleiman AB, Puvaneswary M, Rohana A. Paracetamol: a cause for analgesic nephropathy and end-stage renal disease. Nephron. 1988; 50: 50-4. [PMID: 3050572]
- Toxicity Notes
- Overdose may be nephrotoxic. Drug is major metabolite of phenacetin.