Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Tiagabine
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- 2
- Half-Life (NormalESRD) hours
- 7-9/No change
- Plasma Protein Binding %
- 96
- Volume of Distribution L/kg
- 0.9-1.7
- Dose for Normal Renal Function
- 4 mg qd
- Second Dose
- Second Dose: Increase by 4 mg/day, titrate dose weekly
- Adjustment for Renal Failure Method
-
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [A]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100% [A]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: None, [A]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: None, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: No data, [D]
- References
- Bourgeois BF. Pharmacokinetic properties of current antiepileptic drugs: what improvements are needed? Neurology. 2000; 55: S11-6. [PMID: 11147563] / Ingwersen SH, Pedersen PC, Groes L, Nielsen KK, Aarons L. Population pharmacokinetics of tiagabine in epileptic patients on monotherapy. Eur J Pharm Sci. 2000; 11: 247-54. [PMID: 11042231]
- Toxicity Notes
- Total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or up to 32 mg/day. Total daily dose should be given in divided doses two to four times daily.