Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Phenoxybenzamine
Antihypertensive and Cardiovascular Agents
Cardiovascular Agents
Miscellaneous Cardiac Drugs
- General Toxicity Notes
-
- Excreted Unchanged %
- Unknown
- Half-Life (NormalESRD) hours
- 24/No data
- Plasma Protein Binding %
- Unknown
- Volume of Distribution L/kg
- Unknown
- Dose for Normal Renal Function
- 10 mg q12h
- Second Dose
- Second Dose: 20-40 mg q8-12h
- Adjustment for Renal Failure Method
-
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 1 mg tid [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- Avoid
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Avoid
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Avoid
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50, [D]
- References
- Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
- Toxicity Notes
- The half-life of orally administered phenoxybenzamine is not known; however, the half-life of the IV-administered drug is approximately 24 hours. Avoid in patients with renal insufficiency.