Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Sufentanil
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 2-5/Unchanged
- Plasma Protein Binding %
- 92
- Volume of Distribution L/kg
- 2-3
- Dose for Normal Renal Function
- Anesthetic induction (individualized)
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [B]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- 100% [B]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Not applicable, [D]
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Dose for GFR 10-50,titrate, [D]
- References
- Davis PJ, Stiller RL, Cook DR, Brandom BW, Davin-Robinson KA. Pharmacokinetics of sufentanil in adolescent patients with chronic renal failure. Anesth Analg. 1988; 67: 268-71. [PMID: 2964213] / Fyman PN, Reynolds JR, Moser F, Avitable M, Casthely PA, Butt K. Pharmacokinetics of sufentanil in patients undergoing renal transplantation. Can J Anaesth. 1988; 35: 312-5. [PMID: 2968186] / Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, Perry DS. Postoperative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology. 1985; 63: 708-10. [PMID: 2932984]
- Toxicity Notes
-