Dosing Guidlines for Adults
Drug Detail for Adult Drugs
Propoxyphene
Analgesics
Narcotics and Narcotic Antagonists
- General Toxicity Notes
-
- Excreted Unchanged %
- Hepatic
- Half-Life (NormalESRD) hours
- 9-15/12-20
- Plasma Protein Binding %
- 78
- Volume of Distribution L/kg
- 16
- Dose for Normal Renal Function
- 65 mg PO q6-8h
- Second Dose
-
- Adjustment for Renal Failure Method
- D
- Adjustment for Renal Failure GFR, mL/min >50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min 10-50 [Recommended Level]
- 100% [D]
- Adjustment for Renal Failure GFR, mL/min <10 [Recommended Level]
- Avoid [D]
- Supplement for Dialysis [Recommendation Level]: IHD
- IHD: Avoid
- Supplement for Dialysis [Recommendation Level]: PD
- PD: Avoid
- Supplement for Dialysis [Recommendation Level]: CRRT
- CRRT: Avoid, [D]
- References
- Colburn WA, Inturrisi CE. D-Propoxyphene: accumulation or altered kinetics? [Letter]. Eur J Clin Pharmacol. 1985; 28: 725-6. [PMID: 4065198]
- Toxicity Notes
- Active metabolite norpropoxyphene accumulates in ESRD.